Cobalamin Deficiency in Elderly Patients: A Personal View

نویسندگان

  • Emmanuel Andrès
  • Thomas Vogel
  • Laure Federici
  • Jacques Zimmer
  • Ecaterina Ciobanu
  • Georges Kaltenbach
چکیده

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

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منابع مشابه

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

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Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%...

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عنوان ژورنال:
  • Current Gerontology and Geriatrics Research

دوره 2008  شماره 

صفحات  -

تاریخ انتشار 2008